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马雷课题组系统提出并推进"数字生命(Digital Life)"研究范式,致力于构建可运行、可解释、可预测的生命系统模型。在数字生命建模、神经群体计算机制解析以及生命模拟计算平台建设等方面取得系列原创成果,形成从基础理论到工程平台的系统性研究布局。已发表 90 篇 论文,其中以第一或通讯作者身份发表 46 篇,累计总影响因子超过 417,包括 Nature Communications(2023)、Cell Research(2024 封面文章)、Nature Computational Science(2024 封面文章)、National Science Review(2025)、TPAMI(2026)等高影响力综合/交叉期刊,在人工智能与生命科学交叉领域产生重要学术影响。多项成果获 新华社央视新闻北京卫视Nature 专题报道媒体广泛报道。相关研究在国际上被认为是数字生命研究从"结构建模"迈向"可运行系统"的代表性工作之一,并在国际脑仿真发展报告(State of Brain Emulation Report 2025)中被作为重要进展予以评述。
90
正式发表论文
46
一作 / 通讯作者
417+
总影响因子
28
CCF-A 论文
2
期刊封面文章
Nature Computational Science Cover
Nature Computational Science Cover
IF 18.3 · Vol. 4, Issue 12, Dec 2024
An integrative data-driven model simulating C. elegans brain, body, and environment interactions
Cell Research Cover
Cell Research Cover
IF 28.1 · Vol. 34, Issue 7, Jul 2024
System-level time computation and representation in the suprachiasmatic nucleus

Selected Publications

* corresponding author   # equal contribution
2026
IEEE TPAMI 2026 Learn to Enhance Sparse Spike Streams.
Z. Zhu, L. Hu, T. Hu, L. Ma*, T. Huang.
IEEE Transactions on Pattern Analysis and Machine Intelligence (TPAMI), 2026. CCF-A IF 20.8 DOI
CVPR 2026 Motus: A Unified Latent Action World Model.
H. Bi, H. Tan, S. Xie, ..., L. Ma*, H. Su, J. Zhu*.
IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 2026. CCF-A
CVPR 2026 3D Gaussian Splatting from Unposed Spike Streams.
Y. Guo, T. Hu, L. Hu, L. Ma*, T. Huang.
IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 2026. CCF-A
ICLR 2026 Nano3D: A Training-Free Approach for Efficient 3D Editing Without Masks.
J. Ye, S. Xie, ..., L. Ma*, J. Zhu*.
International Conference on Learning Representations (ICLR), 2026. CCF-A
AAAI 2026 Splats in Splats: Robust and Effective 3D Steganography towards Gaussian Splatting.
Y. Guo, W. Huang, ..., L. Ma*, ..., T. Huang.
AAAI Conference on Artificial Intelligence (AAAI), 2026. CCF-A
AAAI 2026 Can Protective Watermarking Safeguard the Copyright of 3D Gaussian Splatting?
W. Huang, Y. Guo, ..., L. Ma*, ..., T. Huang.
AAAI Conference on Artificial Intelligence (AAAI), 2026. CCF-A
eLife 2026 Domain-adaptive Matching Bridges Synthetic and In Vivo Neural Dynamics for Neural Circuit Connectivity Inference.
..., L. Ma*, ...
eLife, 2026.
2025
Nat. Comput. Sci. 2025 Cost-effective Instruction Learning for Pathology Vision and Language Analysis.
K. Chen, M. Liu, F. Yan, L. Ma, ..., S. Zhang*.
Nature Computational Science, 5: 524–533, 2025. IF 18.3 DOI
Natl. Sci. Rev. 2025 An Initiative on Digital Nephrology: the Kidney Imageomics Project.
F. Zhou, Z. Li, H. Li, ..., B. Dong*, L. Ma*, L. Yang*.
National Science Review, 2025. IF 16.3 DOI
npj Digit. Med. 2025 Pathorchestra: A Comprehensive Foundation Model for Computational Pathology with over 100 Diverse Clinical-grade Tasks.
..., L. Ma, ...
npj Digital Medicine, 2025. IF 15.1
Sci. China Life Sci. 2025 Trans-scale Bioimaging and Integrative Biology: on the Debut of China National Biomedical Imaging Center.
L. Chen*, L. Ma*, H. Dai, Q. Du, Y. Sun, H. Cheng*.
Science China Life Sciences, 2025. IF 8.0 DOI
ICML 2025 MindCustomer: Multi-Context Image Generation Blended with Brain Signal.
M. Yu, S. Lin, L. Ma*, B. Lei*, K. Ma*.
International Conference on Machine Learning (ICML), 2025. CCF-A
CVPR 2025 T3D: Advancing 3D Medical Vision-Language Pre-training by Learning Multi-View Visual Consistency.
..., L. Ma, ...
IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 2025. CCF-A
AAAI 2025 SpikeGS: Reconstruct 3D Scene via Fast-Moving Bio-Inspired Sensors.
Y. Guo, L. Hu, L. Ma*, T. Huang.
AAAI Conference on Artificial Intelligence (AAAI), 2025. CCF-A
MICCAI 2025 A Boundary-Aware Cold-Diffusion Model for Electron Microscopy Segmentation.
..., L. Ma*.
International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI), 2025. CCF-B
2024
Nat. Comput. Sci. 2024 Cover An Integrative Data-Driven Model Simulating C. elegans Brain, Body, and Environment Interactions.
M. Zhao, N. Wang, X. Jiang, X. Ma, H. Ma, G. He, K. Du, L. Ma*, T. Huang.
Nature Computational Science, 4(12): 978–990, 2024. Cover IF 18.3 DOI
Cell Research 2024 Cover System-level Time Computation and Representation in the Suprachiasmatic Nucleus Revealed by Large-scale Calcium Imaging and Machine Learning.
Z. Wang, J. Yu, M. Zhai, ..., L. Ma*, W. Hu*, H. Cheng*.
Cell Research, 34(7): 493–503, 2024. Cover IF 28.1 DOI
IEEE TPAMI 2024 A Bayesian Approach Toward Robust Multidimensional Ellipsoid-Specific Fitting.
..., L. Ma, ...
IEEE Transactions on Pattern Analysis and Machine Intelligence (TPAMI), 2024. CCF-A IF 20.8
IJCV 2024 Light Flickering Guided Reflection Removal.
Y. Hong#, Y. Chang#, J. Liang, L. Ma, T. Huang, B. Shi*.
International Journal of Computer Vision (IJCV), 132: 3933–3953, 2024. CCF-A IF 19.5 DOI
Med. Image Anal. 2024 PathoDuet: Foundation Models for Pathological Slide Analysis of H&E and IHC Stains.
..., L. Ma, ...
Medical Image Analysis, 2024. IF 10.7
Med. Image Anal. 2024 Embedded Prompt Tuning: Towards Enhanced Calibration of Pretrained Models for Medical Images.
W. Zu#, S. Xie#, Q. Zhao#, G. Li, L. Ma*.
Medical Image Analysis, 97, 2024. IF 10.7 DOI
Pattern Recognit. 2024 Coherent Chord Computation and Cross Ratio for Accurate Ellipse Detection.
M. Zhao, X. Jia*, L. Ma*, L.-M. Hu, D.-M. Yan.
Pattern Recognition, 2024. CCF-B IF 8.0
CVPR 2024 Correspondence-Free Non-Rigid Point Set Registration Using Unsupervised Clustering Analysis.
M. Zhao, J. Jiang, L. Ma*, ..., D. Yan.
IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 2024. CCF-A Highlight (~3%) Paper
ACL 2024 CIF-Bench: A Chinese Instruction-Following Benchmark for Evaluating the Generalizability of LLMs.
..., L. Ma, ...
Annual Meeting of the Association for Computational Linguistics (ACL), 2024 (Findings). CCF-A
ACM MM 2024 PRTGS: Precomputed Radiance Transfer of Gaussian Splats for Real-Time High-Quality Relighting.
Y. Guo, Y. Bai, L. Hu, ..., L. Ma*.
ACM International Conference on Multimedia (ACM MM), 2024. CCF-A
NeurIPS 2024 Retrospective for the Dynamic Sensorium Competition.
..., L. Ma, ...
Conference on Neural Information Processing Systems (NeurIPS), 2024. CCF-A
NeurIPS 2024 Learning from Pattern Completion: Self-supervised Controllable Generation.
..., L. Ma, ...
Conference on Neural Information Processing Systems (NeurIPS), 2024. CCF-A
SIGGRAPH Asia 2024 Correlation-aware Encoder-Decoder with Adapters for SVBRDF Acquisition.
..., L. Ma, ...
ACM Transactions on Graphics (TOG) / SIGGRAPH Asia, 2024. CCF-A IF 7.8
ECCV 2024 Learning to Robustly Reconstruct Dynamic Scenes from Low-light Spike Streams.
..., L. Ma*, ...
European Conference on Computer Vision (ECCV), 2024. CCF-B
2023
Nat. Commun. 2023 A GPU-based Computational Framework that Bridges Neuron Simulation and Artificial Intelligence.
Y. Zhu#, G. He#, L. Ma#, X. Liu, ..., S. Grillner, K. Du, T. Huang.
Nature Communications, 14: 5798, 2023. IF 14.7 DOI
Engineering 2023 1000x Faster Camera and Machine Vision with Ordinary Devices.
..., L. Ma, ...
Engineering, 2023. IF 12.8
NeurIPS 2023 Med-UniC: Unifying Cross-Lingual Medical Vision-Language Pre-Training by Diminishing Bias.
Z. Wan, C. Liu, ..., L. Ma, ..., R. Arcucci.
Conference on Neural Information Processing Systems (NeurIPS), 2023. CCF-A
IEEE TPAMI 2023 Hybrid High Dynamic Range Imaging fusing Neuromorphic and Conventional Images.
J. Han, Y. Yang, C. Zhou, P. Duan, L. Ma, C. Xu, T. Huang, I. Sato, B. Shi*.
IEEE Transactions on Pattern Analysis and Machine Intelligence (TPAMI), 45(6): 1234–1245, 2023. CCF-A IF 20.8
IEEE TVCG 2023 Accurate Registration of Cross-Modality Geometry via Consistent Clustering.
M. Zhao, X. Huang, J. Jiang, L. Mou, D.-M. Yan, L. Ma*.
IEEE Transactions on Visualization and Computer Graphics (TVCG), 29(1): 1–12, 2023. CCF-A IF 5.2
NeurIPS 2023 Unsupervised Optical Flow Estimation with Dynamic Timing Representation for Spike Camera.
L. Xia, Z. Ding, R. Zhao, ..., L. Ma, ..., R. Xiong.
Conference on Neural Information Processing Systems (NeurIPS), 2023. CCF-A
2022
CVPR 2022 Optical Flow Estimation for Spiking Camera.
L. Hu#, R. Zhao#, Z. Ding, L. Ma*, B. Shi, R. Xiong, T. Huang.
IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 2022. CCF-A Paper
ACM TOG 2022 Constant-Cost Spatio-Angular Prefiltering of Glinty Appearance Using Tensor Decomposition.
..., L. Ma, ...
ACM Transactions on Graphics (TOG), 2022. CCF-A IF 7.8
IEEE TIP 2022 GraphReg: Dynamical Point Cloud Registration with Geometry-aware Graph Signal Processing.
M. Zhao, L. Ma*, X. Jia, D.-M. Yan, T. Huang.
IEEE Transactions on Image Processing (TIP), 2022. CCF-A IF 10.6
Neural Netw. 2022 Structure Inference of Networked System with the Synergy of Deep Residual Network and Fully Connected Layer Network.
K. Huang, S. Li, W. Deng, Z. Yu, L. Ma*.
Neural Networks, 145: 288–299, 2022. IF 7.8
Front. Comput. Neurosci. 2022 A Theoretical Model Reveals Specialized Synaptic Depressions and Temporal Frequency Tuning in Retinal Parallel Channels.
L. He, Y. He, L. Ma*, T. Huang.
Frontiers in Computational Neuroscience, 16: 1034446, 2022. IF 3.2
Front. Behav. Neurosci. 2022 Siamese Network-Based All-Purpose-Tracker, a Model-Free Deep Learning Tool for Animal Behavioral Tracking.
L. Su, W. Wang, K. Sheng, X. Liu, K. Du, Y. Tian*, L. Ma*.
Frontiers in Behavioral Neuroscience, 16: 759943, 2022. IF 3.3
2021 & Earlier
ACM MM 2021 Milliseconds Color Stippling.
L. Ma*, J. Shi, Y. Chen.
ACM International Conference on Multimedia (ACM MM), 2021. CCF-A
IEEE TVCG 2020 Parallel Computation of 3D Clipped Voronoi Diagrams.
..., L. Ma, ...
IEEE Transactions on Visualization and Computer Graphics (TVCG), 2020. CCF-A IF 5.2
SIGGRAPH 2019 Real-time Structure Aware Color Stippling.
L. Ma, ...
ACM SIGGRAPH, 2019. CCF-A
Google Scholar · 完整 90 篇论文列表请参阅 学术主页